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What medications can damage your kidneys? Which Drugs are Harmful to Your Kidneys? Pain Medications. Your kidneys could be damaged if you take large amounts of over-the-counter medications, such as aspirin, naproxen and ibuprofen. Alcohol. Antibiotics. Prescription Laxatives. Contrast Dye (used in some diagnostic tests such as MRIs) Illegal Drugs. What should you do?
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